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The evidence presented above notwithstanding, the 2020 guidelines for the prevention of CIPN issued by the American Society of Clinical Oncology do not yet endorse GM1 for prevention or treatment of CIPN, citing insufficient evidence (Loprinzi, Lacchetti 2020)

Some of them affect children (degenerations with early onset, such as Friedreichs ataxia, injuries, and tumors in children)

In the EU and other regions, it faces similar restrictions

Zhao G, Sun H, Zhang T, Liu JX

Sound therapy, Tinnitus Retraining Therapy, Cognitive Behavioral Therapy, and lifestyle changes are among the various strategies that can offer relief and improve the quality of life for those suffering from tinnitus