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By adopting a dual-pathway strategytargeting both pain relief and inflammation reductionwe observed significant improvements in joint function during clinical trials involving over 5,000 participants

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On the other hand, a significant increase in TDO expression has been found in preeclampsia, but since inflammatory response is involved in the pathogenesis of preeclampsia, it can be hypothesized that upregulation of TDO cannot fully compensate for the decrease in IDO in this regard

however, its neuroprotective benefits are diminished in Nrf2 knockout mice