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If you've been on 0.5 mg for more than two months without appetite reduction, discuss dose escalation with your provider

NSAIDs, including ibuprofen, have been associated with small increases in cardiovascular risk, particularly with high doses or prolonged use

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She also argued that diabetes is a risk factor for NAION

By contrast, Xu et al (213), using CT26 and SW480 models together with endothelial C166 cells and patient-derived xenografts, reported that GCG administered at 10 nM in vitro and 20 g per mouse daily in vivo for ~14 days inhibited tumor angiogenesis and vascular mimicry and enhanced chemotherapy efficacy, without measurable differences in blood glucose levels among groups