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2023 NEJM) randomized 17,604 adults with overweight or obesity and established cardiovascular disease (without diabetes) to semaglutide 2.4 mg weekly or placebo

Obesity: a much higher study focus than other metabolic disease areas Precisely classifying the clinical trial types in the metabolic domain can be a fraught affair given the variability of descriptions, but taking a conservative approach to classification clearly reveals that trials involving obesity and overweight outnumber those focused more on type 2 diabetes about four to one