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The published research on oral B12 bioavailability consistently shows around 1% absorption meaning of a 1000mcg oral dose, only about 10mcg actually reaches your cells

PMID: 42351772 iScience 2025 Sep 10;28(10):113536

Paclitaxel can disrupt mitochondrial function, resulting in the overproduction of ROS such as superoxide anions and hydroxyl radicals, as well as reactive nitrogen species (Sharifi-Rad et al., 2021)

The weight-skin connection The skin, hair and nails are highly responsive to changes in weight, nutrition, hormones, inflammation and physiological stress

There is also the matter of international market readiness