supplements with semaglutide Ozempic® (semaglutide) GLP-1 RA for Type 2 Diabetes Weight Management for Adults with

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82, 18451851.10.1210/jc.82.6.1845 216 MartiniA

The mechanism by which GLP-1 RAs potentially increase suicide or suicide attempts is unclear but may involve an overactivation of the hypothalamic-pituitary-adrenal (HPA) axis [7], rapid weight loss [8], and reduced expression of brain-derived neurotrophic factor which may link weight changes to heightened anxiety and suicidal risk [9]