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Proc Natl Acad Sci U S A 112:E2517E2526

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Furthermore, LRRK2 and PINK1 can facilitate proteasome degradation of each other to reciprocally down-regulate their protein levels, reaching a functional balance [44]

Thus, microbial changes in PD indicate a shift from a symbiotic, neuroprotective microbiota to a pro-inflammatory, neurotoxic microbial composition, which can promote peripheral immune activation, gut barrier failure, and, eventually, neuroinflammation and dopaminergic neuronal death [44]