The increased risk of amputation seen in the large, long-term Canagliflozin Cardiovascular Assessment Study (CANVAS) trial for canagliflozin, and select observational studies, merits further research but overall, there is currently no consistent evidence of SGLT2i exposure and increased risk of amputation
The efficacy and safety of the combination therapy with GLP-1 receptor agonists and SGLT-2 inhibitors in type 2 diabetes mellitus: a systematic review and meta-analysis
Radiofrequency microneedling offers an effective alternative, said Joseph
In a 26-week study, orforglipron demonstrated a significant dose-dependent effect on weight loss, with weight reduction ranging from 8.6% to 12.6% across various dosages, compared to only 2.0% in the placebo group
Quick Answer: Sulfur burps on GLP-1 medications can be managed through over-the-counter remedies like bismuth subsalicylate, dietary modifications limiting sulfur-rich foods, smaller meal portions, and gradual dose titration under medical supervision