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We found that therapeutic doses decrease liver GSH by only modest amounts (10%), but that overdoses of 10 grams or more severely deplete liver GSH (Figure6)

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Each of those amino acids connects to the next through peptide bonds, and the entire chain folds into a precise configuration that determines how the molecule interacts with receptors in your body

Current second-generation CB1 inhibitors, small molecules potentially more peripherally restricted than rimonabant, still exhibit brain accumulation6 in preclinical models, indicating a possible persistent safety issue