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FilippiVSteigerRBeliveauVFrankFKaltseisKGizewskiERet al

Treatment is subcutaneous and prescribed within a monitored cycle

The integrated peak area of individual markers was normalised by dividing the area of each metabolite by the total peak area of the chromatogram, measured with MarkerView

Semaglutide is a GLP-1R agonist approved for treatment of type 2 diabetes (in doses 0.5-2.0 mg once weekly) and obesity (2.4 mg once weekly) [6,7]

The toxicity increased with the increase in the sulfadiazine concentration extracted by HF-LPME at different pH values, suggesting that the HF-LPME extracted concentration can be used to estimate the toxicity of sulfadiazine independent of the ambient pH, that was the concentrations of sulfadiazine in the test solutions measured by HF-LPME and the corresponding immobilization-concentration-response equation were used to calculate the immobilization ratio