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Nonetheless, the interpretation of current data is limited by detection and prescription biases in observational studies as well as insufficient follow-up and number of events in randomized trials

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Pre-existing pigmented lesions , including melanotic macules and oral naevi, may be the precursor in a proportion of cases, although most oral melanomas appear to arise without an identifiable precursor

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Each will bring its own dosing chart with its own escalation schedule and its own non-transferable milligram numbers