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Their mean plasma ammonia concentration was within the normal range, but 24 patients (35.3%) with ammonia concentrations above 80 g/dl were considered hyperammonaemic and 15 of these 24 (22.1%) had ammonia concentrations above 100 g/dl

AstraZeneca data (20012010) indicated that over 20% of pipeline candidates were halted in the preclinical stage mainly due to toxicity 8 , and industry-wide data (20102017) showed 90% failure in the clinical stage attributed predominantly to clinical efficacy and toxicity 9

10.1016/j.jchf.2023.05.010 [DOI] [PubMed] [Google Scholar] 73.Kato ET, Lewis BS, Ono K

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Glucagon-like peptide-1 receptor agonists significantly affect the quality of bowel preparation for colonoscopy