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10.3389/fnagi.2019.00080 157 KimS.-J.ParkJ.-H.KimK.-H.LeeW.-R.AnH.-J.MinB.-K.et al (2012)

A deeper understanding of these interconnected pathophysiologic mechanisms will facilitate the development of targeted therapies beyond cysteamine, optimizing treatment approaches to mitigate disease progression [146]

Here is how the retatrutide effect compares to other common heart rate influences that most people experience daily without concern: This table demonstrates that the retatrutide heart rate effect falls squarely within the range of everyday physiological variations that healthy hearts handle without difficulty

But at least now we have a background with which to judge the GLP-1s

Thats $36.5 billion between just two drugs