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Chronic inflammation (due to poor diet, infections, stress, etc.) can deplete levels and has been implicated with higher levels of TPO antibodies, as well as higher TSH

Aquac Res 53:15821596 Zhou Q, Wang L, Wang H, Xie F, Wang T (2012) Effect of dietary vitamin C on the growth performance and innate immunity of juvenile cobia ( Rachycentron canadum )

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In comparison to a regular diet, with increased levels of insulin and insulin-like growth factor-1 (IGF-1) creating an anabolic state, the FMD creates a catabolic metabolic state with reduced glucose, insulin, and IGF-1 levels, and increased glucagon, adiponectin, and KBs ( Due to the low carbohydrate intake, FMD has negligible hepatic glycogen stores and biochemically energy metabolism is directed at fat oxidation and ketogenesis