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Most protocols limit consecutive dosing to 1014 days followed by a 24 week washout period before repeating

Adding ceramides, one may be able to minimize these effects

Lilly, the drug maker which funded the second phase of the clinical trial (on humans), announced the phase 2 trial results on Monday (June 26, 2023)

doi: 10.1038/s41581-022-00601-z 70 SpinelliRBabootaRGoggSBeguinotFBlherMNerstedtAet al

Abstract Background This research aimed to explore if carnitine (CARN) deficiency is a risk factor in methotrexate (MTX)-mediated acute kidney injury (AKI) and to mechanistically reveal the potential attenuating effect of CARN against MTX-mediated nephrotoxicity