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Hypomelanotic melanoma is also often difficult to diagnose, as exemplified in a patient with an extensive chronic foot ulcer, in whom attentive dermatoscopic observation revealed that the only atypical pigmented area was at the periphery (Fig

In fact, the major clinical trials showed the exact opposite effect

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However, incorporating a control tube that contains the same biological sample but lacks glutathione substrate can help to identify and prevent the interfering effect of thiols, ensuring more reliable and accurate test results