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no human clinical safety data exists for the KLOW formulation

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Overall, there were no impacts of Protandim supplementation on the antioxidant and inflammatory status of mature sedentary horses as measured by GPx activity, SOD activity, MDA concentration, H 2 O 2 production and concentration, cytokine (IL-4, IL-6, IL-8, IL-10, TNF) concentrations, and Nrf2 , HMOX1 , and IL-1 mRNA expression

Research has identified specific gene variants associated with GLP-1 drug response, but pharmacogenomic testing for GLP-1 medications is not yet standard clinical practice