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Acta Pharm Sin B 12(1):117

It activates the Nrf2 signaling pathway, decreases MDA and cyclooxygenase-2 (COX-2) expression, increases GSH, GPX4, and SLC7A11, inhibits blood creatinine and urea nitrogen retention caused by renal ischemia-reperfusion injury, thus ameliorating renal pathology (189)

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So its called polygenic obesity, and that means many genes are likely involved, and those are passed down, said Poddar

Supplementary material The Supplementary Material for this article can be found online at: References 1 BaiL.WangY.HuoJ.LiS.WenY.LiuQ.et al (2021)