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PMCID: PMC4665094

This dynamic process relies on the coordinated interplay between endothelial cells and vascular smooth muscle cells (VSMCs), which is influenced by neurohumoral factors, locally acting vasoactive mediators, and metabolic signals

The 42 amino acid peptides readily form oligomers that can further accumulate into fibrils and plaques in the brain, which are hallmarks of AD pathology (Cheignon et al., 2017

Comparison of the redox array with conventional proteomic methods confirmed that the redox array is much more sensitive and can be performed using more than 100-fold less protein than is required for methods based on mass spectrometry

Abstract Parkinsons Disease (PD) involves degeneration of dopamine-producing neurons, mitochondrial dysfunction, alpha-synuclein aggregation, neuroinflammation, and gut-brain axis disturbances