[1] Retatrutide (trials): once-weekly subcutaneous administration, starting low (e.g., 2 mg) and escalating to 4, 8, or 12 mg maintenance, with slower titration used to improve tolerability
It can either be used as a preventive or during flare-ups to ease symptoms
Although these findings do not completely exclude the effect on kidney parenchymal cells or off-target effects, these results suggest that sulfasalazine prevents the formation of TLS not by attenuating tubular injury but via its inhibitory effect on of the cystine/glutamate transporter specifically expressed within TLS
Understanding this hierarchy helps set realistic expectations and guides protocol decisions
L-thyroxine administration successfully induced a hyperthyroid state, as evidenced by marked reduction in TSH and elevations in FT3 and FT4 levels, in agreement with previous studies by Samy et al