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As a model for chemotherapy induced infertility we used two chemotherapy agents (doxorubicin and cisplatin), testing three interventions (NMN treatment, NMNAT1-Tg and NMNAT3-Tg overexpression) and using three outcomes for fertility (COC yield, breeding, ovarian histology)

Peptides are short chains of amino acids that act as signaling molecules throughout the body

Williamson KS, Gabbita SP, Mou S, West M, Pye QN, Markesbery WR et al

The protein levels of Nrf2, HO-1, CHOP, and GRP78 were measured by immunofluorescence

Combined data sets were then clustered by hierarchical clustering (using the Manhattan distance and ward.D2 clustering) for both drugs and parameters