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2 However, since GLP-1 is easily degraded within a few minutes by dipeptidyl peptidase 4 (DPP-4), the GLP-1 receptor agonist such as Exenatide and Liraglutide are used to prolong this effect

Interestingly, normal physiological levels of GLP-1 do not significantly stimulate metabolism, but prolonged elevation from receptor agonists can have a meaningful effect

Prescription GLP-1 receptor agonists - semaglutide and tirzepatide - mimic this signal at pharmaceutical concentrations, producing the significant appetite suppression and weight loss outcomes that made them famous