Statistical analyses For analysis with multiple treatment arms, a random-effects model was used in the NMA [66], employing MetaInsight (version 4.0.2, Complex Reviews Support Unit, National Institute for Health Research, London, UK) within a frequentist framework
The cardiovascular outcome data alone, covering nearly 100,000 patients in randomized trials, places this class among the most impactful drug discoveries in modern preventive medicine
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Turnbull FM, Abraira C, Anderson RJ, et Intensive glucose control and macrovascular outcomes in type 2 diabetes