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Collagen typically helps replace dead skin cells
Initial studies in animal models suggested that pineal peptide extracts containing the AEDG sequence might extend lifespan and improve various markers of aging
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Diclofenac (50 g/mL) served as a positive control
This was observed in genetic models of hypertension, such as aged spontaneously hypertensive rats, 111, 112 stroke-prone spontaneously hypertensive rats, 113 Type 2 diabetic, mildly hypertensive GotoKakizaki rats 114 and TGR(mREN2)27 renin transgenic rats, 115 as well as in several models of drug-induced hypertension
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