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Rossignol D, Frye RE

New prescriptions of GLP-1 receptor agonists for the treatment of obesity have increased significantly among individuals without type 2 diabetes in the last decade, according to a study in Annals of Internal Medicine

For example, Novo Nordisk is exploring semaglutide in large-scale clinical trials for Alzheimers, while other biotech startups are assessing GLP-1 analogs in treating opioid dependency

Doses above 2ml per injection show no additional benefit in controlled trials and increase injection site discomfort without improving methylation efficiency