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2 R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

doi: 10.1345/aph.1Q024 88 AstrupACarraroRFinerNHarperAKunesovaMLeanMEJet al

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While the first studies showing this were in mice [14], human studies have corroborated these findings [200], although its importance in relationship to traditional clearance pathways across the BBB and subarachnoidal granulations has been challenging to quantify