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Also, MTX administration leads to inflammatory cascades involving the activation of NF-B, with increased expression of pro-inflammatory cytokines such as IL-6 and TNF-, followed by activation of the JAK/ STAT3 signaling (RFd et al

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The findings may not be generalizable to populations where viral hepatitis, autoimmune hepatitis, or cholestatic liver disease predominate, or to healthcare settings with different standard-of-care protocols, alcohol consumption patterns, or nutritional backgrounds

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