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Critchley JA, Nimmo GR, Gregson CA et al , Inter-subject and ethnic differences in paracetamol metabolism

14,15 Potential Direct Effects on the Heart Although the systemic indirect effects of GLP-1RAs are well established as the primary drivers of their clinical benefit in HF, emerging preclinical and mechanistic evidence suggests GLP-1RAs may also exert some direct cardioprotective effects, as discussed below

Uzun, N., Sarikaya, S., Uluduz, D., and Aydin, A

Outlook Over the next decade, as the oral GLP-1 market rapidly expands, these two distinct molecular approachespeptide and small moleculewill act as strategic complements, jointly driving metabolic disease treatment into an era of unprecedented scale and accessibility.

Firstly, am not a doctor, but this view stems from decades of experience in Healthcare delivery and understanding of incentives of various stakeholders