The olfactory region, more specifically the olfactory bulb, is the only compartment throughout the human body where peripheral regions keep in direct contract with the CNS (Selvaraj et al., 2018)
Semaglutide promotes the transition of microglia from M1 to M2 type to reduce brain inflammation in APP/PS1/tau mice
Likewise, in AD mouse model, scutellarein was reported to inhibit TRPV3 channel activity, accompanied by reduced, accompanied by reduced neural hyperexcitability, lower serum IgE levels, and decreased expression of proinflammatory cytokines including IL-1, TNF-, IL-4, IL-6, and CXCL15 (Wang Y
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