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10.1016/j.euroneuro.2015.04.016 47

Acetaminophen concentrations obtained earlier than 4 hours post-ingestion may be misleading as they may not represent maximum acetaminophen concentrations

In addition, the following additional adverse effects may manifest if a dose larger than 5 grams is administered: Nausea Skin rashes, hives, or allergic reactions Diarrhea Liver, renal, and nerve system toxic effects

doi: 10.1016/S0140-6736(21)00393-7 72

Protocol: Dosing typically follows a titration schedule , starting at a low dose (e.g., 0.3 mg) and gradually escalating every four weeks until the target dose (2.4 mg) is achieved