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Chemical modifications such as lipidation (first applied therapeutically to insulin in the 1990s), PEGylation (established as a platform technology in the early 2000s), and reversible albumin binding have transformed peptides from short-lived signaling molecules into durable therapeutics suitable for weekly or even monthly administration ( In parallel, advances in formulation science and delivery technologies have expanded the feasible routes of peptide administration

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doi: 10.1016/j.cgh.2024.03.013

Explosive market growth for weight-loss medications The GLP-1 market is booming: $26 billion in sales in 2024, projected to hit $100470 billion annually by 2032, dominated by just two pharmaceutical giants: Novo Nordisk and Eli Lilly