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Easy measuring: At 3.33 mg/mL, 1 unit = 0.01 mL 33 mcg on a U-100 insulin syringe

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Regulation of circadian rhythms through pineal gland affecting melatonin production (melatonin has retinal protective properties)

Potential toxicity includes adverse reactions such as serotonin toxicity, especially in patients taking serotonergic drugs