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A new briefing from the Californian-based think tank Pacific Research Institute (PRI) warns that continued large-scale sales are not only putting patients at risk but could wipe out between $9.3bn and $11.8bn in future R&D investment enough to cost the world four to five new medicines

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Lead series optimization Our goal was to enhance interactions of the small-molecule agonists with the GLP-1R through lowering the energy barrier to achieve the receptor-bound agonist conformation, and by adjusting polar substituents, with minimal increases in molecular weight

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The key is comparing actual evidence, not just marketing promises

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Interestingly, only 28.2% of the patients were classified as unwilling to initiate insulin

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