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Although many substrates (therapeutic drugs, environmental chemicals) are glucuronidated by multiple UGTs, several compounds exhibit a relative specificity towards individual UGT enzymes

2.2.1 Initiation and progression of neurodegenerative diseases Each neurodegenerative disease has distinct initiating pathological proteins and vulnerable neuronal populations, but a common theme is that the accumulation of protein aggregates and resulting neuronal stress elicits a sustained immune response in the brain

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Failure to downregulate the BAF53a subunit of the SWI/SNF chromatin remodeling complex contributes to the differentiation block in rhabdomyosarcoma

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