In a recent investigation undertaken by our group, adult mice with partial IGF-1 showed a decrease in the expression of genes involved in glucose metabolism (phosphoenolpyruvate carboxylase-1, glucose-6-phosphatase, pyruvate dehydrogenase kinase isoenzyme-4, and ATP-citrate lyase), resulting serious hyperglycaemia [164]
Worth a read for anyone following obesity care and real-world evidence: To view or add a comment, sign in A diagnostic paradox buried in the Lancet obesity framework: Patient A: HbA1c 6.1% + dyslipidemia meets definition of "clinical obesity" Patient B: HbA1c 6.8% (diagnosed T2DM) + normal lipids may not qualify as "clinical obesity" T2DM was excluded from the organ-dysfunction criteria despite: ~90% of T2DM patients being overweight or obese Strong mechanistic links to visceral & ectopic fat ~50% diabetes remission rate with intensive weight loss at 1 year This inconsistency may create real coverage and access problems
Time your injection strategically Many researchers find that injecting in the evening before bed helps manage initial nausea
Situations Where GLP-1s Cannot Be Paid for with HSA/FSA HSAs and FSAs are easy to use but they still have a few hard nos
Targeting neuroinflammatory pathways therefore represents a critical therapeutic avenue for the development of novel and adjunctive antidepressant strategies (32, 34)
