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It is also unlicensed in the UK, and UK regulators have publicly warned about it

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Loperamide (Imodium) and diphenoxylate (Lomotil), an opioid agonist, are first-line medical treatments for chemotherapy-induced diarrhea

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Read the full study: Long-Term Treatment with Recombinant Insulin-Like Growth Factor (IGF)-I in Children with Severe IGF-I Deficiency Due to Growth Hormone Insensitivity (JCEM 2007)

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Whereas GLP-1 monotherapy slightly reduced plasma aspartate aminotransferase (AST) levels compared with those in MK-801-treated mice, GLP-1MK-801 treatment did not affect plasma AST or alanine transaminase (ALT) levels (Extended Data Fig

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Indeed, GLP-1R agonism slows gastric emptying (51, 52) and suppresses small intestinal motility (53)

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