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CGM for type 2 diabetes For the first time, continuous glucose monitoring (CGM) is recommended for people with type 2 diabetes, including those who are not on insulin

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Published work on intranasal peptide delivery (for insulin analogs, calcitonin, and oxytocin) demonstrates that bioavailability for this size class without enhancers is typically in the low single-digit percent range, though these data are from different peptides with different charge profiles

Primarily summarized into 3 main MOA: MOA: Increases Insulin release/sensitivity, decreases glucagon release MOA: Slows gastric emptying (gastric peristalsis) MOA: Appetite Suppression Patho 101: Plasma glucose is maintained by a tug-of-war between the hypoglycemic effect of insulin and the hyperglycaemic effect of glucagon

Compounding pharmacies operate under FDA regulations which allow them to create drugs exempt from full FDA approval when there is a shortage or a specific patient need