Gopal S, Borovok I, Ofer A, Yanku M, Cohen G, Goebel W, Kreft J, Aharonowitz Y: A multidomain fusion protein in Listeria monocytogenes catalyzes the two primary activities for glutathione biosynthesis
1 It has an estimated prevalence of roughly 6% in the UK
This localized depletion is strongly correlated with increased ventricular lactate, pointing to severe neuroinflammation, an overwhelmed central nervous system antioxidant network, and a direct physiological explanation for the profound cognitive dysfunction and "brain fog" experienced by patients
This metabolic transition is often accompanied by activation of the pentose phosphate pathway (PPP), which may contribute to cellular defense against oxidative stress induced by reactive oxygen species (ROS), as well as a concomitant suppression of gluconeogenesis (Scantlebery et al., 2021
Even more, because of its direct connection to glutathione production