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10.1038/nature01819 145 NogueiraN

Cell 187 , 38293853 (2024)

In the 18-month trial, people with type 2 diabetes and obesity who took the highest (36 milligram) dose of the drug lost an average 10.5% of their starting body weight, researchers reported

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Retatrutide exhibits highest potency at the GIP receptor (8.9-fold greater than endogenous GIP), with moderate activation of the GLP-1 receptor (0.4-fold) and lower, yet functional, glucagon receptor activity (0.3-fold)