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Duodenal activation of cAMP-dependent protein kinase induces vagal afferent firing and lowers glucose production in rats

The intrinsic pathway involves mitochondria-related and endoplasmic reticulum stress pathways, where the Bcl-2 protein family plays a pivotal role by modulating mitochondrial outer membrane permeabilisation (MOMP) [46]

The stress response to surgery, changes in diet and activity, pain medications, and the reintroduction of Ozempic all influence glucose levels in complex ways

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Similarly, CR in this study was designed to match body weights with SEMA group, while other CR approaches may differ 27,28