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Discussion The results of this population based cohort study, designed to emulate a randomised controlled trial, suggest that the combined use of GLP-1 receptor agonists and SGLT-2 inhibitors is associated with a reduced risk of major adverse cardiovascular events and serious renal events, compared with using either drug class alone

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Discussion The relevance of the isoprenaline-induced myocardial infarct is supported by the evidence that catecholamines represent a common pathway in the evolution of myocardial changes in humans who develop myocardial lesions without narrowing or obstruction of coronary arteries [24]