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Peptides and the bloodbrain barrier: lipophilicity as a predictor of permeability

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Furthermore, besides ABBV-3373, a strategy coupling a novel glucocorticoid receptor agonist with an anti-CD74 antibody via a pyrophosphate acetal linker, and a glucocorticoid conjugate targeting CD70, have both demonstrated the feasibility of targeted glucocorticoid delivery in in vitro experiments [91,92]

Chaves LP, Melo CM, Saggioro FP, Reis RBD, Squire JA