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In some instances, sterilization of an auris formulation by filtration through membranes (e.g., 0.2 M membranes) is not possible if the formulation comprises thixotropic polymers that gel during the process of filtration

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It should also be noted that, from a methodological perspective, the model used (Cox with stratification by cardiovascular risk class of the trials, i.e., SURPASS-4: high risk, and all others: low risk) requires various assumptions, including the homogeneity of the relative effect of tirzepatide treatment on MACE regardless of the baseline cardiovascular risk level of the patients