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Description

Changes in zinc concentrations beyond the cells ability to coordinate can lead to tumorigenesis, as zinc provides the bioenergetic/ synthetic requirements of malignancy, such as the aberrant expression of zinc transporters and dysregulation of MTs binding proteins

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DOI: 10.1016/j.peptides.2005.01.029 Anti-Inflammatory Melanocortin Signalling Research using MT-2 as a pharmacological tool has investigated MC3R and MC4R-mediated anti-inflammatory pathways in macrophage, keratinocyte, and neuronal cell models, including NF-B pathway suppression, pro-inflammatory cytokine downregulation, and melanocortin-mediated immune modulation research areas of relevance to neuroinflammation and peripheral inflammatory signalling biology

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Note lesion count when multiple solar lentigines present, categorising distribution as localised (single anatomical site) or generalised (three or more body regions)

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