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The molecular mechanisms demonstrated that HKC notably downregulated the protein expression of NADPH oxidase (NOX)-1, NOX-2, NOX-4, -smooth muscle actin (SMA), and the p-extracellular signal-regulated kinase (ERK)1/2 by inhibiting the NADPH oxidase/reactive oxygen species (ROS)/ERK signaling pathways in renal tissue in rats with chronic renal failure induced by adenine in vivo [40]

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When it came time for the appointments, they took very good care of my son to make sure he was comfortable and also knew everything that he was going to experience