N-acetyl-L-cysteine (NAC), a well-characterized thiol antioxidant and precursor of reduced glutathione (GSH), not only scavenges intracellular ROS directly but also replenishes depleted GSH stores in erythrocytes, thereby inhibiting ROS-mediated Ca 2+ influx and PS externalization induced by eryptosis triggers such as desipramine or uremic toxins
The animals were maintained under standard housing conditions at 22 2 C with 12/12-h light/dark cycles
As the increase of pS6 in cDCs was pronounced in peanut-allergic adults, but not children, with severe clinically proven reactions, our data suggest a possibly novel mechanism, which may contribute to the disease course of food allergy by enhancing antigen-presenting cell functions
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