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Eli Lilly responded to its rivals accusations with a statement saying that the trial which underpins its advertising, known as Surmount-5, is the only direct, head-to-head randomised clinical trial comparing tirzepatide and semaglutide in the context of weight management

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Once activated, these receptors turn key signaling proteins up or down, including GLP-1, ghrelin, CCK, and GIP, which together influence appetite, blood sugar, and fat metabolism

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