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The Phase 3 TRIUMPH-4 trial pushed these numbers even further: participants on retatrutide 12mg lost an average of 28.7% of their body weight at 68 weeks

What they found: Mean weight loss: 2.6 kg vs 2.3 kg placebo , a difference of only 0.3 kg (1 %) Statistically non-significant Clinically unsatisfactory for the obesity indication Safety profile remained favorable Why it matters: The study stopped the development of AOD-9604 as a drug

Scientific explanation: The clearest experimental evidence comes from exercise physiology research, since exercise-induced dehydration is easy to measure and reproduce in a lab setting

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However, beginning with the calendar year (CY) 2012 OPPS/ASC proposed rule, the addenda no longer appear in the Federal Register as part of the annual OPPS/ASC proposed and final rules to decrease administrative burden and reduce costs associated with publishing lengthy tables