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It does not automatically establish sterility, authorisation or suitability for human or veterinary use

Cell 178 , 536551.e514 (2019)

In the Phase 3 REDEFINE 1 trial, CagriSema produced a mean body weight reduction of approximately 22.7% from baseline at 68 weeks in adults with obesity (without type 2 diabetes)

Tirzepatide is a dual-agonist, targeting both GLP-1 and GIP receptors, whereas semaglutide is a single-agonist that targets only GLP-1

[0018] In some particular embodiments of the present invention, the cleaving in the fragmental synthesis of the Lys 26 side chain in the preparation method is performed with 1-2% TFA/CH 2 Cl 2 (V/V) or 20% TFE/CH 2 Cl 2 (V/V)