In this study, we sought to test the hypothesis that ketamine administration in patients with depression leads to an acute increase in glutamatergic activity in the ACC, as measured by 1 H-fMRS, and that pretreatment with the opioid receptor antagonist naltrexone attenuates this increase
Bracke, M.E., Depypere, H.T., Boterberg, T., Van Marck, V.L., Vennekens, K.L.M., Vanluchene, E., Nuytinck, M., Serreyn, R
#### Indications: **Vitamin B12 Deficiency:** Treatment of vitamin B12 deficiency due to malabsorption, dietary insufficiency, or increased physiological needs (e.g., pregnancy, lactation)
It activates one receptor
Focusing clinical trials exclusively on advanced PD populations, where symptomatic medication changes are no longer feasible, also poses significant challenges